OBJECTIVE： To provide reference for improving the reporting of adverse drug reactions （ADRs） in the hospital. METHODS： A questionnaire survey was conducted to investigate the reporting of ADRs and causes of missing reports by medical staff in all departments of a third grade class A hospital. The related data were statistically analyzed. RESULTS： A total of 967 questionnaires were distributed， and 900 questionnaires were collected， with a recovery rate of 93.07％. Among them， 875 were valid questionnaires， and the effective rate was 97.22％. Among the medical staff， who can correctly answer the main causes of ADRs （drugs were toxic， individual difference）， accounted for 42.51％ and 49.26％； 35.89％ of staff did not receive any ADRs training in one year； 33.83％ did not know the ADRs reporting system and ways； 30.06％ would fill in the ADRs statement voluntarily； 61.49％ considered that the absence of full-time personnel was the main difficulty in reporting ADRs； 41.60％ indicated that they had previously reported ADRs. The causes of missing ADR reports by medical staff were ranked as high to low： uncertainty about ADRs， and there was no relevant information in the hospital （accounting for 45.94％）； the filling process of ADR reports was complicated （accounting for 34.97％）； do not have the phone number of ADR supervision department in hospital （accounting for 33.60％）； do not know the reporting process （accounting for 33.49％）， and so on. CONCLUSIONS：The situation of ADR reporting by medical staff in the hospital is not satisfactory， most of them have varying degrees of missing ADRs. The inadequate management and publicity of ADR monitoring， poorly trained by the hospital is an important reason for missing reporting.