OBJECTIVE： To conduct the economic evaluation of recombinant human type Ⅱ tumor necrosis factor receptor- antibody fusion protein （trade name： Etanercept） in the treatment of rheumatoid arthritis. METHODS： By literature retrieval， foreign literatures about Etanercept “head to head” research or Chinese literatures about the comparison of recombinant human type Ⅱ tumor necrosis factor receptor-antibody fusion protein with infliximab and adalimumab were collected. The costs were localized， indicators of effectiveness were converted into quality-adjusted life year （QALY），then cost-utility analysis （CUA） and incremental cost-utility ratio （ICUR） were conducted. RESULTS： Three qualified literatures were acquired. The translational research of the first report of WU B and so forth （2012 year） showed that CUA of Etanercept， infliximab and adalimumab were 48.2， 36.6 and 104.6 thousand yuan/QALY， and ICUR were 119.8， 116.4 and 313.4 thousand yuan/QALY， respectively. The translational research of the second report of Santos-Moreno P and so forth （2015 year） showed that CUA of Etanercept， infliximab and adalimumab were 93.1， 118.2 and 249.2 thousand yuan/QALY， and ICUR were 117.5， 151.3 and 327.9 thousand yuan/QALY， respectively. The translational research of the third report of Santos-Moreno P and so forth （2016 year） showed that CUA of Etanercept， infliximab and adalimumab were 107.0， 131.6 and 273.8 thousand yuan/QALY， and ICUR were 139.6， 172.5 and 369.8 thousand yuan/QALY， respectively. ICUR of Etanercept were all smaller than 3 times of GDP 148.1 thousand yuan in 2015. CONCLUSIONS： From the results of the study of these 3 literatures， compared with infliximab and adalimumab， Etanercept shows economy for rheumatoid arthritis.