OBJECTIVE： To observe the clinical efficacy and safety of additional use of Cypate gingival fluid in periodontal basic therapy before surgery in the treatment of pregnancy gingival tumor. METHODS： A total of 86 patients with pregnancy gingival tumor in Second Affiliated Hospital of Qiqihar Medical University during Jan. 2015 to Jan. 2016 were divided into observation group and control group according to random number table， with 43 cases in each group. Control group received ligation and oral micro-electrosurgical surgery according to the volume of tumor. Observation group was given Cypate gingival fluid-based periodontal basic therapy （3-5 mL for gargling， 2-3 min each time， 3-5 times each day， 5 d） and then receive surgery. Clinical efficacies， gingival related indexes （gingival index， sulcular bleeding index， probing depth）， quality scores of life， ADR， the occurrence of complications were observed in 2 groups. The followed-up was conducted 1 year after surgery， and the recurrence of gingival tumor was compared between 2 groups. RESULTS： No case was found shedding in the study. The total response rate of observation group was 97.67％， which was significantly higher than 79.07％ of control group （P＜0.05）. After treatment， the gingival related indexes of 2 groups were decreased significantly compared to before treatment， while quality scores of life were increased significantly compared to before treatment， observation group was significantly better than control group （P＜0.05）. No severe ADR or complication was found in 2 groups during treatment. Recurrence rate of gingival tumor in observation group was 2.33％， which was significantly lower than 13.95％ in control group 1 year after treatment （P＜0.05）. CONCLUSIONS： Compared with surgery alone， additional use of Cypate gingival fluid in periodontal basic therapy before surgery has better clinical efficacy and lower recurrence rate， with good safety.