OBJECTIVE： To provide reference for the formulation of clinical therapy plan for elderly patients with vaginal infection. METHODS： From Jun. 2014 to Oct. 2016， 200 elderly patients with vaginal infection were selected from Wuhan Wuchang Hospital （called our hospital for short）. Leucorrhea routine examination， bacterial culture， identification and drug sensitivity test were all performed for the secretions of vaginal side wall. The occurrence of vaginal infection was compared among different age groups. The distribution of bacteria， distribution of cleanliness and drug resistance were observed. RESULTS： The types of vaginal infectious diseases in 200 patients included Candida vaginitis， Trichomonas vaginitis， bacterial vaginitis， nonspecific vaginitis. The incidence of vaginal infection in 66-70 age group was significantly higher than 60-65 age group and 71-80 age group，the incidence of vaginal infection in 60-65 age group was significantly higher than 71-80 age group， with statistical significance （P＜0.05）. A total of 205 strains of bacteria were detected， most of which were Gram-positive bacteria， except for Escherichia coli. Streptococcus was the most common pathogen， with a total of 76 strains （37.07％）， followed by Staphylococci （48 strains， 23.41％）. The vaginal secretion cleanliness was grade Ⅰ， Ⅱ， Ⅲ and Ⅳ respectively in 10， 70， 90， 30 cases. The amount of bacteria increased with the increase of vaginal secretion cleanliness， and Streptococcus and Staphylococcus infection were the most common in patients with Ⅲ to Ⅳ degree. Resistance rate of bacteria to penicillin， gentamicin and erythromycin were relatively higher while most of them to teicoplanin and linezolid were relatively lower； they were all sensitive to vancomycin （resistance rate of 0）. CONCLUSIONS： There are many types of vaginal infectious diseases in our hospital， and most of them are 66-70 years old. The majority of bacteria were Gram-positive bacteria， most of them were Streptococcus. The drugs which are sensitive to pathogen include vancomycin， teicoplanin and linezolid. Antibiotics should be rationally selected according to drug sensitivity test.