OBJECTIVE： To provide reference for standardizing clinical pharmacist training. METHODS： According to actual situation in our hospital， a new clinical pharmacist training teaching method [lecture-based learning （LBL）-case-based learning （CBL） combination method] was created by integrating the training resources of clinical teaching and research department and extending teaching content.  The comprehensive skills of trainees after training were compared between 2015 （traditional one-to-one teaching model） and 2016 （LBL-CBL combination method）. RESULTS & CONCLUSIONS： In 2016， trainees are significantly improved in the ability to analyze （3.8 score vs. 2.8 score） and deal with clinical problems （2.9 score vs. 2.5 score） compared with those in 2015. LBL-CBL combination method can satisfy the demands of clinical pharmacists training in our hospital. Not only basic theory and clinical knowledge of trainees are improved， but also clinical thinking and comprehensive skill of trainees are strengthened by using LBL-CBL combination method. LBL-CBL combination method can be used in clinical pharmacists training and its usual tests， and contributes to the improvement of clinical pharmacist training teaching.