OBJECTIVE： To observe clinical efficacy and safety of Bufeihuayu decoction combined with chemotherapy in the treatment of non-small cell lung cancer （NSCLC） and its effects on vascular endothelial growth factor （VEGF） and immune function. METHODS： A total of 120 NSCLC patients in our hospital during Oct. 2013 to Jun. 2015 selected as research object were divided into observation group and control group according to random number table， with 60 cases in each group. Control group was given GP （gemcitabine combined with cisplatin） chemotherapy. Observation group was additionally given Bufei huayu decoction， one dose a day， decocted to 400 mL， morning and night， on the basis of control group. Clinical efficacies of 2 groups were compared， and VEGF-A， VEGF-B， VEGF-C and immune indexes （CD3+， CD4+， CD8+， CD4+/CD8+） levels were compared before and after treatment. The occurrence of toxic reaction was recorded. RESULTS： Response rate and disease control rate of observation group were 58.33％ and 85.00％， significantly higher than 40.00％ and 68.33％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in levels of VEGF or immune indexes between 2 groups （P＞0.05）. After treatment， VEGF of 2 groups were decreased significantly， and observation group was significantly lower than the control group， with statistical significance （P＜0.05）； CD4+ and CD4+/CD8+ of 2 groups were decreased significantly， while CD8+ was increased significantly， with statistical significance （P＜0.05）； CD4+ and CD4+/CD8+ of observation group were significantly higher than those of control group， while CD8+ was decreased significantly； CD3+ of control group was decreased significantly and lower than observation group， with statistical significance （P＜0.05）. The incidence of leucopenia， thrombocytopenia， decrease of hemoglobin， elevation of transaminase， increase of bilirubin and digestive tract reaction in observation group was significantly lower than control group， with statistical significance （P＜0.05）. CONCLUSIONS： Bufei huayu decoction combined with chemotherapy shows significant therapeutic efficacy for NSCLC， can effectively inhibit VEGF， improve immune function and relieve toxic reaction.