OBJECTIVE： To construct integrated medication decision-making system， and to provide reference for safe， effective， economical and reasonable drug use in clinic. METHODS： The construction of integrated medication decision-making system was introduced in our hospital. RESULTS & CONCLUSIONS： The integrated medication decision-making system included three aspects as real-time intervention in advance， interactive review in the matter， afterward comment and analysis， as 3 steps before and after the implementation of inpatient medical order and outpatient prescription. The real-time intervention in advance was mainly to control the rationality of medical orders or prescriptions from their source， thus requiring the timely treatment. The interactive review in the matter required that pharmacists judged the medical order or prescription and made a decision of refusing prescribing within the fixed time. To make a decision accurately， the clinical information should be highly structured and correlated with drug signs. Afterward comment and analysis required that pharmacists evaluated the medical order or prescription regularly after the implementation. The three were not only different， but also coordinated， and they were an organic unity， especially interactive review in the matter needed to be coordinated with the other two processes. After the implementation of integrated medication decision-making system， the proportion of irrational medical orders or prescriptions in our hospital decreased from 6.07％ in the first half of 2016 to 2.56％ at corresponding period of 2017. Drug dose errors and incompatibility were greatly reduced， and medication against contraindications was more likely to be found in the review and analysis. The system can improve the efficiency of prescription review， improve rational drug use， and effectively ensure the safety， effectiveness， economy and rationality of clinical drug use.