OBJECTIVE： To prepare Dexzopiclone orally disintegrating tablets （DODT）， and to optimize its formulation. METHODS： Direct powder compression method was used to prepare DODT. Using repose angle of material， disintegration time and taste evaluation as indexes， single factor test was used to screen the types or amount of bulking agent， disintegrating agent， glidant and flavoring agent； using disintegration time as index， orthogonal experiment was applied to optimize the proportion of bulking agent， the amount of disintegrating agent， glidant and flavoring agent. Then the hardness and main component contents of DODT prepared by optimal formulation were determined. RESULTS： The optimal formulation was as follows as the ratio of mannitol-MCC 1 ∶ 4， the amount of disintegrating agent PVPP was 15％， the amount of glidant magnesium stearate was 1.0％， the amount of flavoring agent stevia was 3.0％. Three batches of prepared DODT were smooth in surface and good in taste； their disintegration time were（26.7±1.2）， （26.7±0.6）， （27.6±0.9）s， hardness were （3.59±0.19）， （3.49±0.18）， （3.27±0.16） kg， and contents were （99.47±0.15）％，（99.53±0.05）％，（99.46±0.20）％， respectively （all RSDs≤0.87％，n＝3）. CONCLUSIONS： Prepared DODT are all in line with the quality requirements of orally disintegrating tablets.