OBJECTIVE： To provide reference for postoperative rational selection of analgesia drugs and the optimization of analgesia plan. METHODS： From the aspect of clinical pharmacists， postoperative pain therapy drugs involved in 6th-22nd chapter of Guidelines for Postoperative Pain Management （called Guideline for short） in the United States. RESULTS： The contents of the Guideline involving postoperative pain therapy drugs included the selection of perioperative therapy drugs and route of administration， multimodal analgesic delivery regimen， individualized drug treatment program， medication monitoring， medication education and postoperative pain management program， etc. The preoperative application of opioids or non-steroidal anti-inflammatory drugs was not recommended in the Guideline due to not benefit from it； for patients who can be given drugs orally， oral administration should be preferred if opioids were administered， and intramuscular injection should be avoided. The multimodal analgesic treatment plan combined with non-drug intervention were recommend for postoperative pain. The individualized treatment plan should be chosen according to the patient’s specific condition. Clinical pharmacists should pay attention to the degree of sedation respiration and the occurrence of ADR in the patients after surgery， and explained the postoperative pain management process， methods of reducing analgesic drugs after discharge to the patiens and their families. CONCLUSIONS： The Guideline about analgesic regimens requirements for perioperative patients provides a reference for clinicians to choose the appropriate individual analgesic regimen.