OBJECTIVE： To optimize the extraction technology of Compound radix fici hirta granule. METHODS： Using the transfer rate of psoralen and amygdalin in extraction liquid of Compound radix fici hirta granule and extraction rate as indexes，    U12 （6×4×3） uniform design was used for the test， the effects of amount of adding water， extraction time， extraction times on the extraction technology were investigated， and optimized technology was verified by three pilot scale tests. RESULTS： The optimal technology was as follow as 10-fold water， extracting for 3 times， 60 min each time. Under the conditions， transfer rate of psoralen and amygdalin and extraction rate were 82.51％ （RSD＝1.45％， n＝3）， 93.69％ （RSD＝0.85％， n＝3）， 18.89％ （RSD＝0.74％， n＝3）， respectively. The validated results were in the 95％ confidence interval of predictive value. CONCLUSIONS： The optimized extraction technology is stable and feasible， and provides the scientific basis for the follow-up development of the preparation.