OBJECTIVE： To compare therapeutic efficacy of rosuvastatin vs. atorvastatin for blood lipid， atherosclerosis and vascular endothelial vasodilation in patients with coronary heart disease （CHD）. METHODS： A total of 150 CHD inpatients selected from cardiovascular medicine department of our hospital during Jan. 2014-Dec. 2015 were divided into rosuvastatin group （72 cases） and atorvastatin group （78 cases） according to lottery method. All patients were adjusted to living habits， given antiplatelet and blood pressure regulating drugs and other basic treatment. At the same time， rosuvastatin group was given Rosuvastatin calcium tablets 10 mg， po， once a night； atorvastatin group was given Atorvastatin calcium tablets 20 mg， po， once a night. Both groups received treatment for 6 months. The levels of blood lipid indexes （TC， TG， HDL-C， LDL-C）， IMT， Crouse scores， Gensini scores and the changes of brachial artery diameter （D） were compared between 2 group before and after treatment. The occurrence of ADR was recorded.  RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， the levels of TC， TG， LDL-C， IMT， Crouse scores and Gensini scores in 2 groups were decreased significantly， while the levels of HDL-C and D values were increased significantly， compared to before treatment； the levels of TC， TG， LDL-C， Crouse score and Gensini score in rosuvastatin group were significantly lower than atorvastatin group， and D value was significantly higher atorvastatin group， with statistical significance （P＜0.05）. There was no statistical significance in the levels of HDL-C or IMR between 2 groups （P＜0.05）. During treatment， dizziness occurred in a patient of rosuvastatin group and relieved spontaneously. Four patients in each group had slight elevation of transaminase， and could be reduced to normal after liver protection treatment. CONCLUSIONS： Rosuvastatin shows more significant therapeutic efficacy than that of atorvastatin in reducing blood lipid， improving AS and vascular endothelial vasodilation in CHD patients with good satety.