OBJECTIVE： To investigate the effects of loading-dose rosuvastain before early percutaneous coronary intervention （PCI） on reperfusion arrhythmias in patients with acute non-ST-segment elevation myocardial infarction （NSTEMI）. METHODS： A total of 136 patients with NSTEMI were randomly divided into loading-dose group （68 cases） and control group （68 cases）. Both groups who were not given anti-platelet drugs were given loading-dose of Aspirin enteric-coated tablets 300 mg+Clopidogrel sulfate tablets 600 mg immediately after admission. The patients who were given aspirin regularly were given loading-dose of Clopidogrel sulfate tablets 600 mg only once after admission. The patients who were given clopidogrel regularly were given loading-dose of Aspirin enteric-coated tablets 300 mg only once. Those received PCI 12-24 h after medication. After PCI， they took Aspirin enteric-coated tablets 100 mg for life+Clopidogrel bisulfate tablets 75 mg at least 12 months. Loading-dose group was given loading-dose of Rosuvastatin calcium tablets 20 mg orally， 12 h before surgery. All patients began to take Rosuvastatin calcium tablets 10 mg， once a day， since the night after the operation. Coronary angiography and the occurrence of reperfusion arrhythmia were observed in 2 groups. The levels of CK-MB and cTnT， major adverse cardiovascular events （MACE） were observed before and after surgery. RESULTS： There was no statistical significance in the number of diseased vessels， culprit vessels， the degree of culprit vessels stenosis or the incidence of MACE between 2 groups （P＞0.05）. The incidence of reperfusion arrhythmia in loading-dose group was significantly lower than control group， with statistical significance （P＜0.01）. There was no statistical significance in the degree of culprit vessels stenosis between 2 groups （P＞0.05）. Before surgery， there was no statistical significance in the levels of CK-MB or cTnT between 2 groups （P＞0.05）. After surgery， the levels of CK-MB and cTnT in 2 groups were significantly higher than before surgery， but the loading-dose group was significantly lower than the control group， with statistical significance （P＜0.01）. CONCLUSIONS： Preoperative loading-dose of rosuvastatin before PCI can reduce the incidence of reperfusion arrhythmias in NSTEMI patients.