OBJECTIVE： To establish the method for simultaneous determinations of rutin， forsythin and platycodin D in Sangju ganmao pills. METHODS： HPLC-MS method was adopted. The determination was performed on Waters Atlantis C18 column with mobile phase consisted of acetonitrile-0.1％ formic acid （gradient elution） at the flow rate of 0.2 mL/min. The column temperature was set 35 ℃， and sample size was 10 μL. The ionization mode was electrospray ion， and the reaction mode was multi-reaction monitoring. By positive ion detection mode， the drying gas and nebuliser gas were all high purity nitrogen. The drying gas temperature was 270 ℃.The drying gas flow rate was 25 L/min. The sheath gas flow rate was 10 L/min. The capillary voltage was 4 500 V. The nozzle voltage was 2 000 V and the scanning time was 0.1 s. RESULTS： The linear range of rutin， forsythin and platycodin D were 0.010 82-2.164 μg/mL （r＝0.999 7）， 0.010 18-2.036 μg/mL （r＝0.999 4），0.010 27-2.054 μg/mL （r＝0.999 7）， respectively. The limits of quantification were 1.250，0.260，2.720 ng/mL， and the limits of detection were 0.380，0.078， 0.820 ng/mL. RSDs of precision， stability and reproducibility tests were all no more than 3.0％. The recoveries were 97.88％-99.88％ （RSD＝0.72％，n＝6），98.48％-103.13％（RSD＝1.91％，n＝6）， 98.79％-101.41％（RSD＝1.05％，n＝6）. CONCLUSIONS： This method is simple， precise， stable and reproducible， and can be used for simultaneous determination of rutin， forsythin and platycodin D in Sangju ganmao pills.