OBJECTIVE： To investigate the general regularity and characteristics of propylthiouracil （PTU）-associated small vasculitis （ASV）， and to provide reference for rational drug use in the clinic. METHODS： ADR/ADE case reports of PTU-ASV published during 1990-2016 were retrieved. The data of 118 ADR cases were analyzed statistically. RESULTS： The incidence of PTU-ASV was higher in female and was highest in 18-59 age group. Drug dose of 87 patients were within 600 mg/d， and the incidence of PTU-ASV was the highest within 1-5 years after medication. Main clinical manifestations were renal and lung function injury. After drug withdrawal， 59 patients received hormone therapy， and 30 patients received hormone combined immunosuppressive agent. Finally，115 patients were recovered and 3 patients died. CONCLUSIONS： In older to reduce or avoid the occurrence of ADR， it is necessary to regularly check antineutrophil cytoplasmic antibody related indexes and evaluate the symptoms of ADR.