OBJECTIVE： To put forward relevant suggestions for promoting the R&D cooperation in biomedical field in China. METHODS： Information of all invention co-patents in biomedical fields during 2000-2015 in patent database was collected， including year， patent name， application number， applicant， patent address， etc.， and descriptive statistical analysis was conducted. RESULTS： The number of invention co-patents in biomedical fields had been increasing year by year， and the number of invention co-patents in 2015 was about 9 times than that in 2000. Invention co-patents mainly came from Beijing， Shanghai and Guangdong， accounting for 49.1％. The top 15 applicants had 983 invention co-patents in total， accounting for 8.9％ of the total number of co-patents，7 of which were enterprises. And in the invention co-patents applied by the top 10 cities for GDP ranking in 2014， invention co-patents applied by enterprises， scientific research institutions （include hospitals） and universities accounted for 56.2％ of all patents. CONCLUSIONS： The R&D cooperation in biomedical fields has mainly focused on a few developed provinces and cities， with low concentration of invention co-patents； the R&D cooperation is mainly led by enterprises， and hospitals have low participation. The government should establish national biomedical information sharing platform， raise the R&D cooperation awareness of large-scale pharmaceutical enterprises and encourage hospitals to actively participate in R&D cooperation activities in biomedicine fields.