OBJECTIVE： To reduce the incidence of irrational medical orders for parenteral nutrition， and promote the rational use of parenteral nutrition. METHODS： The medical orders for parenteral nutrition of the first quarter of 2016 in general surgery department of our hospital were collected， and the number and types of its irrational medical orders were summed up. Then FOCUS-PDCA （Find-organize-clarify-understand-select-plan-do-check-act） cycle management was adopted to analyze and improve the existing problems in issuing medical orders for parenteral nutrition. The improved （the third quarter of 2016） medical orders for parenteral nutrition were collected， the number and types of its irrational medical orders were summed up， and management effect was evaluated. RESULTS： Establishing nutrition support group， strengthening the training and communication of medical staff， adding prescription evaluation module for parenteral nutrition in hospital information system and a number of measures had made the incidence of irrational medical orders for parenteral nutrition in general surgery department declined from 48.25％ （1 433/2 970） before improvement to 5.67％ （120/2 118） after improvement. The incidences of cation excess， inappropriate selection of drugs and inappropriate compatibility in irrational types were 0. CONCLUSIONS： FOCUS-PDCA cycle management can reduce the irrational rate of medical orders for parenteral nutrition and promote the rational use of parenteral nutrition in hospital.