OBJECTIVE： To evaluate clinical efficacy of Angong niuhuang pill combined with chemical drug in the treatment of severe craniocerebral injury and its effect on the concentration of Mg2+ in peripheral blood， and to provide evidence-based reference in clinic. METHODS： Retrieved from Chinese Journal Full-text Database， China Science and Technology Journal Database， China Bxdxiology Medicine disc， Wanfang Database， Chinese Clinical Trial Registry， PubMed， Excerpta Media Database， The Cochrane Library， Web of Science， Clinical Trials， and related literatures of internet searched by Google Scholar， randomized controlled trials （RCT） about Angong niuhuang pill combined with chemical drug （trial group） vs. chemical drug （control group） in the treatment of severe craniocerebral injury and its effects on the concentration of Mg2+ in peripheral blood were collected. After literature screening， data extraction， quality evaluation with modified Jadad scale， meta-analysis of Glasgow Coma Scale（GCS） scores and Mg2+ concentration in peripheral blood were conducted by using Rev Man 5.3 statistical software after 7 d of treatment. RESULTS： A total of 6 RCTs were included， involving 773 patients. Results of meta-analysis showed that GCS [MD＝2.87，95％CI（1.64，4.10），P＜0.01] and Mg2+ concentration in peripheral blood [MD＝0.11，95％CI（0.06，0.16），P＜0.01] of trial group were significantly higher than those of control group， with statistical significance. CONCLUSIONS： Therapeutic efficacy of Angong niuhuang pill combined with chemical drug is better than that of chemical drug alone in the treatment of severe craniocerebral injury， can improve clinical symptom and prognosis.