OBJECTIVE： To optimize the formulation of ferulic acid ligustrazine （FATM） solid lipid nanoparticles （FATM- SLN）， and conduct the quality evaluation. METHODS： Emulsification ultrasonic method was used to prepare FATM-SLN. Using particle size and entrapment efficiency as indexes， amount of glyceryl monostearate， egg yolk lecithin （PC）， poloxamer 188 （P188）， and sodium stearate as factors， single factor test and orthogonal test were used to optimize the formulation； and verification test was conducted. The appearance morphology， distribution of particle size， Zeta potential， stability and in vitro release degree of prepared FATM-SLN were investigated. RESULTS： The optimal formulation was as follows as FATM of 10 mg， glyceryl monostearate of 300 mg， PC of 200 mg， P188 of 200 mg， sodium stearate of 10 mg， and purified water of 20 mL. The prepared FATM-SLN showed spherical solid particles， appearance morphology was round， distribution of particle size was 40-800 nm， particle size was 106.23 nm， polydispersity index was 0.254， Zeta potential was －34.8 mV， entrapment efficiency was 73.32％， drug loading was 1.20％； the appearance had no obvious changes within 10 d in 4 ℃ （RSD＜2％）. The drug-release in 0.5-1 h was the fastest， the cumulative release degree reached to 60.47％； it tended to be stable after 8 h， the cumulative release degree reached to 93.46％， and drugs were basically released completely. CONCLUSIONS： FATM-SLN formulation is successfully optimized， and the prepared FATM-SLN has small particle size， high entrapment efficiency and good stability.