OBJECTIVE： To investigate clinical efficacy and safety of Xingnaojing injection in the treatment of acute cerebral infarction， and its effects on neurological function， activities of living， inflammatory factors and coma score. METHODS： Ninety patients with cerebral infarction admitted in Chongqing People’s Hospital from Jun. 2015 to Jan. 2016 were divided into control group and observation group according to random number table， with 45 cases in each group. Control group was given conventional treatment as Clopidogrel bisulfate tablets 75 mg，po，qd+ Nimodipine tablets 20 mg，po，tid. Observation group was additionally given Xingnaojing injection 20 mL added into 0.9％ Sodium chloride solution 250 mL， ivgtt， qd， on the basis of control group. Both groups received treatment for consecutive 14 d. Clinical efficacies of 2 groups were observed. NIHSS scores， Barthel indexes， Glasow coma scale and the levels of TNF-α and IL-6 were also observed before and after treatment. The occurrence of ADR was recorded. RESULTS： The total response rate of observation group （91.11％） was significantly higher than that of control group （73.33％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in NIHSS scores， Barthel indexes， Glasow coma scale or the levels of TNF-α and IL-6 between 2 groups （P＞0.05）. After treatment， NIHSS scores， the levels of TNF-α and IL-6 in 2 groups were decreased significantly， while Barthel indexes were increased significantly； the improvement of above indexes in observation group were significantly better than control group， with statistical significance （P＜0.05）. Fourteen days after treatment， Glasow coma scale of control group was significantly higher than before treatment； 1， 5， 14 d after treatment， Glasow coma scale of observation group was significantly higher than before treatment， and significantly higher than that of control group， with statistical significance （P＜0.05）. Total incidence of ADR in observation group （6.67％） was significantly lower than control group （13.33％）， with statistical significance （P＜0.05）. CONCLUSIONS： Xingnaojing injection shows significant therapeutic efficacy for acute cerebral infarction， can effectively improve the neurological function， activities of living， the regain of consciousness， and can reduce the level of inflammatory factor with good safety.