OBJECTIVE： To investigate the effects of Fluorouracil implants on intraperitoneal chemotherapy safety of advanced gastric cancer patients. METHODS： The information of 264 patients with advanced gastric cancer were analyzed retrospectively. All patients were given Fluorouracil implants 800 mg， scattered into the mesenteric and surgical area， dose of each implantation site less than 200 mg， the distance of implantation range from incision and anastomosis more than 3 cm. All patients were given second generation cephalosporin 30 min before operation， at 3rd h during operation，1-3 d after operation. The occurrence of complications and ADR during hospitalization were observed after operation. RESULTS： After operation， 6 patients suffered from complications， with incidence of 2.28％， including 3 cases of gastrointestinal reaction， 2 cases of anastomotic bleeding and 1 case of anastomotic leakage. Routine blood test and liver and kidney function were rechecked 3 d after operation， mainly thrombocytopenia and liver function injury， with the incidence of 2.65％. CONCLUSIONS： Fluorouracil implants can be used for intraperitoneal chemotherapy of advanced gastric cancer patients. However， attention should be paid to thrombocytopenia and liver function injury.