OBJECTIVE： To study the effect of Shui medicine Asarum insigne polysaccharide on glycolipid metabolism， renal function and oxidative stress in rats with experimental type 2 diabetes， and provide reference for its development and use. METHODS： 60 SD rats were randomly divided into normal control group， model control group， positive control group （Irbesartan tablets， 0.02 g/kg） and A. insigne polysaccharide low-dose， medium-dose， high-dose groups （calculated by crude drug as 2， 4， 8     g/kg）， 10 in each group. Except for normal control group， rats in other groups were intraperitoneally injected streptozotocin 75   mg/（kg·d） to induce model with diabetes. After modeling， rats in each administration group were intraperitoneally injected relevant medicines， and rats in normal control group and model control group were intragastrically administrated 5％ carboxymet hylcellulose sodium solution， twice a day， for 42 d. After administration， UV spectrophotometer was used to detect the glycogen content in liver tissue. Automatic biochemical analyzer was used to detect 24 h urine output， 24 h urinary protein content of rats， levels of triglyceride （TG）， cholesterol （TC）， low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）， creatinine （Cr）， urea nitrogen （BUN） in serum， and levels of superoxide dismutase （SOD）， glutathione peroxidase （GSH-Px）， catalase （CAT）， superoxide dismutase （ROS）， malondialdehyde （MDA） in kidney tissue. RESULTS： Compared with normal control group， glycogen content in liver tissue of rats in model control group was decreased （P＜0.05）； 24 h urine output and 24 h urinary protein content were increased （P＜0.05）； levels of TG， TC， LDL-C in serum were increased （P＜0.05）， and HDL-C level was decreased （P＜0.05）； levels of SOD， CAT， GSH-Px in kidney tissue were decreased （P＜0.05）， and levels of ROS， MDA were increased （P＜0.05）. Compared with model group， except that there were no significant differences in the improvement of urinary protein content， HDL-C level in serum， 24 h urine output in A. insigne polysaccharide low-dose group， above-mentioned indexes in each administration group were obviously improved （P＜0.05）. CONCLUSIONS： A. insigne polysaccharide can regulate lipid metabolic disorders， and improve renal function and antioxidant capacity of rats.