OBJECTIVE： To investigate the clinical efficacy and safety of atorvastatin calcium combined with probucol in the treatment of atherosclerosis. METHODS： A total of 80 patients with atherosclerosis selected from the Affiliated Hospital of Sichuan College of TCM during Jan. 2015-Jan. 2016 were randomly divided into control group and observation group according to random number table， with 40 cases in each group. Control group was given Probucol tablet 0.5 g， every 2 days. Observation group was additionally given Atorvastatin calcium tablet 20 mg， qd， on the basis of control group. Both groups were treated for consecutive 24 weeks. The levels of blood lipid， arterial plaque size and thickness before and after treatment， life quality score before treatment and 3 months after treatment were observed in 2 groups； and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in blood lipid， arterial plaque size and thickness or life quality score between 2 groups （P＞0.05）. After treatment， the levels of TC， TG and LDL-C， arterial plaque size and thickness in 2 groups were decreased significantly， while HDL-C level and life quality score were increased significantly； the improvement of above indexes in observation group was significantly better than control group， with statistical significance （P＜0.05）. There was no statistical significance in total incidence of ADR between observation group （12.50％） and control group （15.00％）（P＞0.05）. CONCLUSIONS： Atorvastatin calcium combined with probucol in the treatment of atherosclerosis can reduce blood lipid level and get thrombolysis， and contribute to the recovery of living ability with good safety.