OBJECTIVE： To strengthen the management and risk control of 4 kinds of special drugs in pharmacy intravenous admixture service （PIVAS）， and promote the drug use safety. METHODS： The 4 kinds of special drugs （high-alert drugs， hazardous drugs， important drugs/costly drugs and drugs needed for skin allergy test） in PIVAS were precisely managed by classification. The effect evaluation was carried out by tracer methodology. RESULTS： The 4 kinds of drugs were classified and managed by developing specified directory， mading special logo， fixing position storage， strengthening medical order review， establishing emergency plan， daily inventory， batch number management， etc. It had standardized the management and use process of high-alert drugs， ensured the operational safety for hazardous drug and occupational protection， made the compliance rate reached 100％ of important drugs/costly drugs， and ensured the consistency of preparation and use batch number of drug for skin allergy test basically. Compared with before management （2015）， the items ratio achieving good level （class B） and above in 18 evaluation indicators had increased from 22.23％ to 94.44％ after management （2016）. CONCLUSIONS： The precise management by classification in PIVAS of our hospital has better controlled the management and risk of 4 kinds of special drugs in clinical use， and ensured the safe operation of PIVAS.