OBJECTIVE： To explore the effects of angiotensin converting enzyme inhibitors （ACEI）/angiotensin Ⅱ receptor blockers （ARB） on the prognosis in patients with advanced gastric cancer complicated with hypertension. METHODS： By retrospective study， clinical information of histologically confirmed Ⅲ-Ⅳ stage advanced gastric cancer patients with hypertension receiving 2 cycles of first-line chemotherapy plan containing fluorouracil at least were collected from Zhejiang Tumor Hospital during Jan. 1st， 2009-Dec. 31th， 2012. The data were summarized and analyzed. The patients receiving ACEI/ARB drugs were included in trial group， and the patients receiving other antihypertensive drugs were included in control group. Telephone follow-up was conducted in 2 groups. RESULTS： A total of 124 patients meeting the inclusion criteria were enrolled in this study. There was no statistical significance in age， gender， smoking history， ECOG score，  family history of disease， family history of tumor， TNM staging， pathological type， tumor site or chemotherapy plan between trial group （23 cases） and control group （101 cases）， except for history of alcohol intake （P＞0.05）. Total response rate of first-line chemotherapy was 73.9％ in trial group， which was significantly higher than 41.6％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in 1-year or 3-year survival rate between 2 groups （P＞0.05）. Median survival time of trial group was 669 d， which was significantly longer than 410 d of control group， with statistical significance （P＜0.05）. Results of COX regression analysis showed that therapeutic efficacy of first-line chemotherapy influenced the survival of patients in different antihypertensive agent groups （P＜0.05）. CONCLUSIONS： Compared with other antihypertensive drugs， ACEI/ARB agents significantly improve response rate of first-line chemotherapy in patients with advanced gastric cancer complicated with hypertension， significantly prolong median survival time， but have no significant effect on survival rate； at the same time， statistical comparison of definite drinking amount are absent.  It needs to be further confirmed by multi-center， prospective and large-scale sample.