OBJECTIVE： To provide reference for reducing the clinical return of finished infusions. METHODS： Interventions for clinical return of PIVAS finished infusions in our hospital were introduced， the return situation of finished infusions before （during 2013-2014） and after （during 2015-2016） intervention was compared， and intervention effects were evaluated. RESULTS： Our hospital intervened it by rationally selecting and using syringes， strengthening visible particle check of finished infusion before distribution； optimizing the order of drug configuration， reasonably arranging the drug infusion sequence； strengthening the clean-up in work area before drug infusion， correctly using disinfectant； strictly implementing intravenous infusion associative operation， playing the role of pharmacists； cultivating good work habits， and strengthening teamwork， etc. Compared with before intervention， the return numbers of finished infusion were decreased by 41.2％， and reported loss amount reduced by 45.7％. The return caused by visibility particles， finished infusion oxidation discoloration after too long storage time， finished infusion leakage， continuous infusion of drugs compatibility， heterodyne error， improper drug configuration method in packaging to the ward， improper use of disinfectant before infusion decreased by 25.3％， 46.9％， 39.4％， 77.8％， 73.9％， 75.0％， 100％， respectively. CONCLUSIONS： Intervening the return of finished infusion can reduce the return numbers and drug waste.