OBJECTIVE： To observe clinical efficacy and safety of recombinant human endostatin （rh-endostatin） combined with CT-guided percutaneous microwave ablation in the treatment of non-small cell lung cancer （NSCLC） complicated with chronic obstructive pulmonary disease （COPD）. METHODS： A total of 80 cases of NSCLC complicated with COPD were selected from our hospital during Feb. 2014-Feb. 2016， and then divided into  control group and observation group according to random number table， with 40 cases in each group. Control group was treated by CT-guided percutaneous microwave ablation. Observation group was additionally given rh-endostatin injection 7.5 mg/m2， once a day， d1-14， added into 500 mL 0.9％ sodium chloride injection， ivgtt lasting for 4 h， for consecutive 14 d， on the basis of control group； 7 d later， next course was performed. A treatment course lasted for 21 d， and they received 4 courses of treatment. Survival time， clinical efficacy as well as KPS score and lung function indexes before and after treatment， the occurrence of ADR were compared between 2 groups. RESULTS： Median survival time of observation group （19.8 months） was significantly longer than that of control group （15.2 months）， and total response rate of observation group （72.5％） was significantly higher than that of control group （55.0％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in KPS score， FEV1， FEV1/FVC or DLCO between 2 groups （P＞0.05）. After treatment， KPS score and above lung function indexes levels of 2 groups were increased significantly， and those of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）. No grade Ⅳwas found in 2 groups. There was no statistical significance in the cases of ADR at different levels between 2 groups （P＞0.05）. CONCLUSIONS： rh-endostatin combined with CT-guided percutaneous microwave ablation in the treatment of NSCLC complicated with COPD show good clinical efficacy with less ADR， and can significantly improve lung function and quality of life.