OBJECTIVE： To investigate the effects of clopidogrel combined with aspirin on related indexes of patients with cerebral infarction induced by middle cerebral artery stenosis in stable phase. METHODS： Clinical data of 127 patients with cerebral infarction induced by middle cerebral artery stenosis in stable phase were analyzed retrospectively and divided into observation group （65 cases） and control group （62 cases） according to therapy drugs. Both groups received routine treatment. Control group was additionally given Aspirin enteric-coated tablet 200 mg orally， once a day. Observation group was additionally given Clopidogrel sulfate tablet 75 mg orally， once a day， on the basis of control group. Both group received treatment for consecutive 1 year. Coagulation function related indexes [D-dimer， PLT， AA-induced platelet inhibition rate， ADP-induced platelet inhibition rate]， daily life quality score [modified Fugl-Meyer scale， Barthel indexes， NIHSS score] before and after treatment， the occurrence of 1-year accumulative cerebral infraction recurrence and ADR were observed and compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， D-dimer level and NIHSS score of 2 groups were significantly lower than before treatment， and the observation group was significantly lower than the control group； AA-induced platelet inhibition rate， ADP-induced platelet inhibition rate， Fugl-Meyer score and Barthel indexes of 2 groups were significantly higher than before treatment， and the observation group was significantly higher the control group， with statistical significance （P＜0.05）. The recurrence rate of 1-year accumulative cerebral infraction in observation group was significantly lower than control group， with statistical significance （9.23％ vs. 22.58％， P＜0.05）. No severe ADR was found in 2 groups during treatment. CONCLUSIONS： Compared with aspirin alone， aspirin combined with clopidogrel in the treatment of cerebral infarction induced by middle cerebral artery stenosis in stage phase can effectively improve coagulation function and quality of daily life， reduce recurrence rate with good safety.