OBJECTIVE： To study the improvement effects of citalopram combined with huperzine A in aged depression model rats. METHODS： Aged rats were randomly divided into blank control group， model group， huperzine A group （0.3 mg/kg）， citalopram group （5 mg/kg）， and combination group （huperzine A 0.3 mg/kg+citalopram 5 mg/kg）， 10 in each group. Except for blank control group， rats in other groups received chronic unpredictable mild stress to reduce depression model. After modeling， rats were intragastrically administrated relevant drugs once a day， for 2 weeks. The depression， learning and memory behavior changes of rats in each group were observed by using open-field test， sucrose consumption test， tail suspension test， forced swimming test and Morris water maze test. RESULTS： Compared with blank control group， the horizontal crossing number， uprightness number， sucrose preference rate， crossing number in platform， percentages of target quadrant distance and time of rats in model group were obviously decreased （P＜0.05 or P＜0.01）； immobility time of tail suspension and swimming， escape latency were obviously prolonged （P＜0.05 or P＜0.01）. Compared with model group， the depression-related indexes of rats in citalopram group and combination group were obviously improved （P＜0.05 or P＜0.01）， and combination group had better effects； the learning and memory-related indexes in combination group were obviously improved （P＜0.05 or P＜0.01）， only crossing time in platform in huperzine A group and citalopram group were obviously increased （P＜0.05 or P＜0.01）， and other learning and memory-related indexes had no obvious changes （P＞0.05）. CONCLUSIONS： Citalopram combined with huperzine A can obviously improve the depression behavior， learning and memory ability of aged rats with depression， showing better effects than citalopram alone.