OBJECTIVE： To provide reference for setting reasonable medicines insurance payment price in China. METHODS： We retrieved and analyzed academic articles formally published at home and abroad， official websites and government documents， summarized.medicines insurance payment pricing mechanism as well as fair solutions to high-cost medicines， so as to put forward the suggestions to formulate reasonable medicines pricing policy in China. RESULTS&CONCLUSIONS： The international medicines payment prices are usually determined by internal reference pricing method， incremental cost-effectiveness evaluation method and external reference pricing method. The sustainable and fair accessibility of high-cost medicines are promoted by fair medicines pricing program， medicines patent pool， open source medicines discovery znitiative and so on. After the goal of universal health care has been achieved in china， reasonable medical insurance payment price should be explored and formulated. It is necessary to adopt， internal reference pricing method to determine the payment standard of completitive eneric products， external reference pricing method or incremental cost-effectiveness evaluation method to determine the reference price for price negotiation of the innovative patented medicines； the concept of fair pricing for high-cost medicines.