OBJECTIVE： To investigate the characteristic and regularity of antineoplastics-induced ADR， and to provide reference for safety use of antineoplastics in clinic. METHODS： In retrospective study， 309 cases of antineoplastics-induced ADR collected from a special hospital during Jan.-Dec. 2015 were summarized and analyzed statistically. RESULTS： Among 309 ADR cases， female （58.25％） was more than male （41.75％）. The patients aged more than 40 years old occupied the highest proportion （78.64％）. Main route of administration was intravenous dripping （94.82％）. There were 225 cases of severe ADR （72.82％）. Total 268 cases were improved after drug withdrawal or treatment （86.73％）. A total of 24 kinds of antineoplastics were involved in 309 ADR cases； most of ADR were induced by docetaxel， followed by cisplatin， cyclophosphamide. Most common organs/system involved in ADR was hemopoietic system （64.24％）， main clinical manifestation was myelosuppression. CONCLUSIONS： It is necessary to strengthen ADR monitoring， prevent， discover and treat antineoplastics-induced ADR timely， in order to reduce the harm to the patients and ensure the safety and effectiveness of drug treatment.