OBJECTIVE： To provide reference for improving the teaching quality of the course of Drug Abuse and ADR Monitoring in pharmacy master degree candidates. METHODS： In Pharmacy College of Jilin University， traditional teaching method was adopted among pharmacy master degree candidates of grade 2014 （n＝30， control group）； case teaching method was adopted for the course of Drug Abuse and ADR Monitoring among those of grade 2015 （n＝32， observation group）. The teaching effects were evaluated by questionnaire and examination. RESULTS： Theoretical examination result and case analysis score as well as the rate of excellent case analysis score in observation group were all significantly higher than control group， with statistical significance （P＜0.05）. The satisfaction degree of observation group was significantly higher than that of control group in respects of teaching methods， arousing interest in classroom learning， establishing the awareness of safe and rational drug use， with statistical significance （P＜0.05）. CONCLUSIONS： For the course of Drug Abuse and ADR Monitoring in pharmacy master degree candidates， case teaching method improves students’ exam results， stimulates students’ interest and enthusiasm， promotes the establishment of students’safe and rational drug use consciousness and improves teaching quality.