OBJECTIVE： To promote the standardization and rationality of medical order for chemotherapeutic drugs， and improve its safety use in clinic. METHODS： Through developing the investigation of relevant status quo， the design factors and information that should be involved and considered of the medical order management module for chemotherapeutical drugs in hospitalized information system（HIS） were determined. The reference standard chemotherapy regimen used in medical orders was put forward. The basic data was maintained and menu setting was conducted. Based on HIS， the function module of automatically importing patients’ information， drug and program selection， warning  were designed； the docking and effective application of medical order management module for chemotherapeutical drugs in hospital medical order management information system was achieved. Its application effects were evaluated by summarizing monthly irrational rate of medical orders within 2 years. RESULTS & CONCLUSIONS： The medical order management module for chemotherapeutical drugs developed in our hospital can achieve physician authorized management， automatically importing patient-related information， preservative chemotherapy regimen for easy entry and selection. The irrational numbers of chemotherapy orders were decreased from 28 orders （1.15％） in prime （Jun. 2014） to 4 orders （0.14％） 2 years later （Jun. 2016）. Procedures of medical orders for chemotherapeutical drugs are standardized， initially realize information management， improve input efficiency and accuracy of medical orders， which have provided protection and support for standardizing physicians’ diagnosis and treatment behavior and avoiding the hospital risk， and promote correct， safe and rational use of chemotherapeutic drugs.