OBJECTIVE： To investigate the clinical efficacy and safety of Recombinant human interferon α2b （rhIFN α2b） vaginal effervescent capsules combined with radiofrequency ablation in the treatment of cervical erosion with human papilloma virus （HPV） subclinical infection （SPI）. METHODS： A total of 207 cervical erosion patients with SPI were selected from gynecology outpatient department of our hospital during Jul. 2014-Aug. 2015 and then divided into group A， B， C according to random number table， with 69 cases in each group. Group A was given rhIFN α2b vaginal effervescent capsules 800 thousand IU， via posterior fornix， qd， 3 days after the end of menstruation， 10 days as a treatment course， for 3 courses. Group B received radiofrequency ablation. Group C was given constant dose of rhIFN α2b vaginal effervescent capsules combined with radiofrequency ablation. The clinical efficacy of 3 groups， the rate of wound healing， the rate of associated symptoms disappearance 2 weeks after surgery and the incidence of complications in group B and C were evaluated. The occurrence of ADR was recorded. RESULTS： The response rates of group B， C were 94.20％ and 98.55％， which were significantly higher than 62.32％ of group A. The response rates of SPI in group C was 92.75％， which was significantly higher than 63.77％ of group B， with statistical significance （P＜0.05）. The wound healing rates of group B 4，6，8 weeks after surgery were 10.14％，43.48％，97.10％； and those of group C were 52.17％，92.75％，100.00％.The wound healing rates of group C 4，6 weeks after surgery were significantly higher than those of group B， with statistical significance（P＜0.05）.The disappearance incidence of symptom as vaginal bleeding and drainage in group C 2 weeks after surgery was 81.16％，which was significantly higher than 43.48％ of group B， with statistical significance （P＜0.05）.The incidences of complications were 11.60％ in group B and 4.35％ in group C，without statistical significance （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： rhIFN α2b vaginal effervescent capsules combined with radiofrequency ablation can effectively improve the efficacy of cervical erosion with SPI， shorten the wound healing time with good safety.