OBJECTIVE： To introduce the research and application of sentinel hospital pharmacovigilance system， and provide technical reference for hospital pharmacovigilance working in China. METHODS： A sentinel hospital pharmacovigilance system based on hospital information system was established， the architecture and functionality were introduced and its effects were analyzed. RESULTS： The sentinel hospital pharmacovigilance system formed by hospital business information management platform and data center. Its main functions included drug data arrangement， the auxiliary reporting of ADR， active monitoring， pharmacovigilance information inquiry， monitoring and warning and statistical analysis， which successfully achieved the rapid reporting and active monitoring of hospital ADR. The system had applied in 20 sentinel hospitals， and the ADR reporting quantity was obviously increased after applying the system. Compared with 2015， ADR reporting in a sample sentinel hospital was increased 120.6％ since it used the system in early 2016. Besides， the system had improved the ADR reporting process， operation and input standard for the ADR reporter， shortened the reporting time and improved the efficiency of the reporting staff. CONCLUSIONS： The establishment and application of sentinel hospital pharmacovigilance system has greatly improved the hospital ADR monitoring management level， and it is of great significance to further strengthen the pharmaovigilance in China.