OBJECTIVE： To investigate the effects of Danhong injection combined with low molecular weight heparin （LMWH） on clinical symptoms， serum inflammatory factors and lung function in elderly patients with chronic obstructive pulmonary disease （COPD）. METHODS： A total of 146 elderly patients with COPD were randomly divided into observation group and control group， with 73 cases in each group. Both groups received conventional treatment. On this basis， control group was given Danhong injection 30 mL， intravenous drip， once a day. Observation group was additionally given LMWH sodium injection 5 000 IU， subcutaneously， twice a day， on the basis of control group. Both groups were treated for 14 d. Clinical efficacies of 2 groups were observed and compared. The clinical symptom score， the levels of IL-6， IL-8，TNF-α， FEV1， FEV1/FVC， pa（O2）， pa（CO2） and the occurrence of ADR were compared before and after treatment. RESULTS： After treatment， the total response rate of observation group was significantly higher than that of control group （93.15％ vs. 78.08％，P＜0.05）. Before treatment， there was no statistical significance between above indexes （P＞0.05）. After treatment， individual clinical symptom score， total clinical symptom score， the levels of IL-6， IL-8，TNF-α， pa（CO2） in 2 groups were significantly lower than before； the observation group was significantly lower than the control group； FEV1， FEVl/FVC， pa（O2） were significantly higher than before， and the observation group was significantly higher than the control group， with statistical significance （P＜0.05）. CONCLUSIONS： Based on conventional treatment， Danhong injection combined with LMWH is effective in the treatment of senile COPD， and can significantly improve the clinical symptoms， serum inflammatory factors levels and pulmonary function with good safety.