OBJECTIVE： To provide reference for ensuring safe and effective drug use in obstetrics and gynecology outpatient department. METHODS： Medication education intervention was conducted among some patients in obstetrics and gynecology outpatient department from 4 third grade class A hospitals of our province through making Wechat pushing messages， videos and leaflets. The difference of rational drug use knowledge awareness and compliance was compared before and after intervention by questionnaire survey. RESULTS： A total of 60 questionnaires were distributed， and 60 valid questionnaires were collected with effective recovery rate of 100％. Compared to before intervention， correct rate of 20 questions about the knowledge of rational drug use were improved after intervention in respects of awareness and compliance. The awareness and compliance scores about the knowledge of rational drug use after intervention were higher than before intervention； there was statistical significance in Wechat pushing message group [（53.18±11.51） vs.（88.48±7.12），（55.15±11.82）vs.（86.81±7.69）]， in video group [（49.50±17.23） vs.（85.00±11.55），（52.00±17.70）vs.（86.00±6.99）]， in leaflets group[（41.47±9.14）vs.（77.05±9.36），（43.23±10.89）vs.（78.82±9.11）] before and after intervention （P＜0.05）. There was no statistical significance in the improvement of awareness or compliance score among those groups （P＝0.992 and P＝0.397）. CONCLUSIONS： Three intervention methods can effectively improve the awareness and compliance of patients about rational drug use knowledge in obstetrics and gynecology outpatient department. Pharmacists can choose the appropriate medication education intervention based on the patient’s different educational levels， preferences and acceptability.