OBJECTIVE： To provide reference for further standardizing and perfecting the management of drug unpacking in outpatient pharmacy. METHODS： A total of 6 primary and secondary health institutions （4 community health service centers and 2 secondary hospitals） were selected from 2 districts in Shanghai to conduct a questionnaire survey on the use of their drugs and drug unpacking in outpatient pharmacy. The survey data was analyzed statistically. RESULTS： Totally 6 institution questionnaires and 6 pharmaceutical staff questionnaires were sent out， all were received with recovery of 100％. In 2015， the average number of essential medicines in community health service centers and secondary hospitals were 496.50， 542.00， respectively， and the average number of varieties sold were 530.75， 1 052.00. In outpatient pharmacy of surveyed community health service center， the number of unpacked drugs was 10-21 which were essential drugs and class A medical insurance drugs， and the consumption sum of unpacked drug ranged 5.56-16.70 ten thousand yuan. In outpatient pharmacy of 2 two secondary hospitals， the number of unpacked drugs were 17 and 23，respectively， most of which were essential drugs and class A medical insurance drugs， and the consumption sum of unpacked drug ranged 13.19 to 158.06 ten thousand yuan. The proportion of unpacked drugs was less than 5％ of the total number of varieties sold， and the proportion of consumption sum of unpacked drugs was less than 1％ of total consumption sum. Estazolam tablets and Alprazolam tablets took up the top 5 in the list of consumption sum of unpacking drugs in 2 types of intervi ewed instiutions. All the surveyed institutions were not equipped with drug dispensing machine in the outpatient pharmacy， still depended on manually unpacking. There were four institutions to regularly arrange the unpacking， unpacking frequency was usually 1 to 3 times a week， supplemented by the need to arrange unpacking， and another two to implement a daily unpacking. There were 5 institutions to develop a drug unpacking mechanism in the institutions， but the relevant system was not perfect. CONCLUSIONS： The enthusiasm of pharmaceutical saff in primary and secondary health institutions in Shanghai to carry out or engage in unpacking work need to be improved， the instructions for unpacked drugs are not available on request， and the way to unpack drugs still needs to explore.