OBJECTIVE： To study the effects Weide’an tablet on gastric function and the expressions of epidermal growth factor （EGF） and its receptor （EGFR） in gastric tissue of model rats with stress-induced gastric injury， and investigate its mechanism in the treatment of gastric ulcer. METHODS： Rats were randomly divided into normal group （normal saline）， model group （normal saline）， positive group （ranitidine hydrochloride， 0.015 mg/kg） and Weide’an tablet high-dose， medium-dose， low-dose groups （1.7， 0.87， 0.43 g/kg）， 10 in each group. Except for normal group， rats in other groups were given fasting swimming in cold water to induce gastric ulcer model. After modeling， all rats were intragastrically administrated once a day， for 2 weeks. The body mass of rats in 0， 7， 14 d of administration was recorded. After 12 h of last administration， gastric juice secretion， gastric juice pH， gastric ulcer area and gastric mucosal damage index of rats were detected， and the expressions of EGF and EGFR in gastric tissue were detected. RESULTS： Compared with normal group， body mass and gastric juice pH in 7， 14 d in model group were declined； gastric juice secretion and gastric ulcer area were increased， gastric mucosal damage index was increased； and the expressions of EGF and EGFR in gastric tissue were enhanced， with statistical significances （P＜0.05 or P＜0.01）. Compared with model group， except that the body mass， gastric juice secretion， gastric juice pH and gastric ulcer area in Weide’an medium-dose group in 7 d， and body mass， gastric juice secretion， gastric juice pH， gastric ulcer area and the expression of EGF in gastric tissue in Weide’an low-dose group in 7， 14 d were not significantly improved， above indexes were significantly improved in other administration groups （P＜0.05 or P＜0.01）； and the effect of Weide’an tablet showed a certain dose-effect relationship. CONCLUSIONS： Weide’an tablet can significantly improve the gastric function of model rats with stress-induced gastric injury； and the mechanism may be related with enhancing the expressions of EGF and EGFR and promoting ulcer healing.