OBJECTIVE： To observe clinical efficacy and safety of Bushen sanhan tongluo decoction combined with moxibustion and celecoxib in the treatment of knee osteoarthritis （KOA）. METHODS： A total of 70 KOA patients were selected from Chongqing Kanghua Hospital during May 2014-Dec. 2015， and then divided into observation group and control group according to odd and even number， with 35 cases in each group. Control group was given Celecoxib capsule 0.2 g， qd； observation group was additionally given Bushen sanhan tongluo decoction （one dose a day， 300 mL， decocted with water， taking it 3 times in the morning， noon and night） and moxibustion. A treatment course lasted for 4 weeks， and both received 2 courses of treatment. Clinical efficacies as well as TCM syndrome score， VAS score， WOMAC score， lab indexes， joint condition before and after treatment， the occurrence of ADR were compared between 2 groups. RESULTS： Total response rate of observation group （85.71％） was significantly higher than control group （68.57％）， with statistical significance （P＜0.05）.  Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， TCM syndrome score， VAS score， WOMAC score， erythrocyte sedimentation rate， CRP level and knee swelling score of 2 groups were decreased significantly， compared to before treatment； those indexes of observation group were significantly lower than those of control group， with statistical significance （P＜0.05）. There was no statistical significance in the number of bone fricative joint between 2 groups before and after treatment （P＞0.05）. There was no statistical significance in the incidence of ADR （5.71％ vs. 2.86％） between 2 groups （P＞0.05）. CONCLUSIONS： Bushen sanhan tongluo decoction combined with moxibustion and celecoxib can improve clinical symptoms， relieve joint pain， joint inflammation and swelling of KOA patients with good safety.