OBJECTIVE： To investigate the compatible stability of Xiao’aiping injection combined with 3 kinds of common injections. METHODS： Referring to package inserts， Xiao’aiping injection 40 mL was compatible with 5％ Glucose injection， 10％ Glucose injection or 0.9％ Sodium chloride injection 160 mL， respectively. At room temperature （about 25 ℃） and high temperature （40 ℃）， the appearance of mixtures were observed at 0， 1， 2， 4， 8， 12， 24， 48 h； pH value and the number of insoluble particles were detected. The contents of tenacissoside A and tenacissoside I in mixtures were determined by HPLC. RESULTS： Under above condition， the mixtures were brownish yellow liquid within 48 h after Xiao’aiping injection was compatible with 5％ Glucose injection or 10％ Glucose injection； 24 h after mixed with 0.9％ Sodium chloride injection， the mixture changed from brownish yellow to reddish brown， but no precipitation was found. The pH value of mixtures had no significant change （RSD＜1％，n＝8）. The number of particles ≥25 μm was in line with the requirements of Chinese Pharmacopeia （2015 edition）. Forty-eight hours after mixing， the number of particles ≥10 μm in the mixtures exceeded the pharmacopoeia limits. Within 48 h after mixing， the relative contents of tenacissoside A and tenacissoside I in mixtures had no significant change （RSD＜2％，n＝8）. CONCLUSIONS： The mixture should be used up within 24 h after Xiao’aiping injection combined with 5％ Glucose injection， 10％ Glucose injection or 0.9％ Sodium chloride injection.