OBJECTIVE： To prepare aspirin phospholipid complex （ASP-PC） and conduct the characterization. METHODS： Using the combination rate of ASP and PC as index， single factor test was used to screen the preparation method of ASP-PC， PC type， solvent type， reaction time， reaction temperature， solvent volume and drug-lipid ratio. The verification test was conducted. UV spectrophotometry， Thermogravimetric analysis， X-ray diffraction and Fourier transform infrared spectroscopy were used for the characterization of ASP-PC. RESULTS： Magnetic stirring-condensing reflux method was adopted， drug-soybean phospholipids ratio was 1 ∶ 3 （mol/mol）， solvent was tetrahydrofuran， reacting for 3 h under 58 ℃. The average combination rate of prepared ASP-PC was 83.52％ （RSD＝1.16％， n＝3）. Compared with ASP， physical mixture of ASP and PC， UV spectrum showed that ASP-PC had no new absorption peak. Thermogravimetric analysis， X-ray diffraction and Fourier transform infrared spectroscopy showed the ASP and PC in ASP-PC were interacted； and ASP-PC changed little in quality within 0-300 ℃. CONCLUSIONS： ASP-PC can be successfully prepared， in which， ASP and PC were combined successfully； while there are still trace amounts of ASP in the form of crystals.