OBJECTIVE： To provide reference for improving therapeutic efficacy of methadone hydrochloride in maintenance treatment for drug addicts. METHODS： A questionnaire survey was conducted among drug addicts from outpatient department of drug maintenance treatment in 2 hospitals of Zhongshan City about their situation and demands. The data were statistically analyzed. RESULTS： A total of 101 questionnaires were distributed， and 88 effective questionnaires were recovered with effective recovery of 87.13％. 64.77％ of the respondents had abused one or more drugs （narcotics） in the last year except for methadone hydrochloride； among them， the frequency of heroin abuse was the highest， which is 31.31％， followed by Qutong tablet， valium， meth， tramadol， etc. 72.73％ of the respondents said they could stick to methadone hydrochloride maintenance treatment completely. The dosage of methadone was relatively dispersed， and the average dosage was 75.80 mL/time； the proportion of 71-80 mL/time was high， accounting for 26.14％. The average score of respondents’ family support was （6.22±1.88） and the average score of social support was（32.73±6.94）. The proportions of general， poor and very poor economic condition were 52.27％，22.73％，14.77％， respectively. The main demand of the top 5 respondents were to eliminate social discrimination （38.64％）， employment （35.23％）， psychological emotional support （35.23％），to reduce methadone hydrochloride dose （32.95％），assisting to reduce relapse （28.41％）， respectively. CONCLUSIONS： The majority of the addicts who receive methadone hydrochloride maintenance treatment are male and middle-aged and young， their relative economic status is poor， and their family care and social support are unsatisfactory. The vast majority of them can adhere to methadone hydrochloride maintenance treatment completely or basically， most of which still abuse other drugs （narcotics） and have many demands. It is necessary to connect “biological-psychological-social” mode of medical treatment through social work intervention service mode， and conduct comprehensive intervention in order to better meet the relevant requirements and improve therapeutic efficacy of methadone hydrochloride maintenance treatment.