OBJECTIVE： To optimize the extraction technology of Yigu granule. METHODS： L9（34） orthogonal test was used， using comprehensive scores of transfer rate of icariin， gentiopicroside， loganic acid and yield rate as evaluation indexes， alcohol volume fraction， the amount of solvent， extraction times and extraction time as investigation factors， extraction technology of Yigu granule was optimized， and the verification test was conducted. RESULTS： The optimized extraction technology was 10-fold 60％ ethanol reflux extraction for twice， 1 h once. Results of verification test showed， average transfer rates of icariin， gentiopicroside and loganic acid were 81.28％ （RSD＝1.54％， n＝3）， 48.71％ （RSD＝2.37％， n＝3） and 59.82％ （RSD＝2.52％， n＝3）； average yield rate was 31.48％ （RSD＝1.97％， n＝3）. CONCLUSIONS： The optimized extraction technology for Yigu granule is stable and feasible with good reproducibility， which can provide basis for the follow-up study of production process.