OBJECTIVE: To optimize the extraction technology for organic acids in Crataegi fructus. METHODS: Based on single factor test, using liquid-solid ratio, extraction time and ethanol volume fraction as independent variables, extraction yield of organic acids as dependent variable, central composite design-response surface method was used to optimize the extraction technology of organic acids in Crataegi fructus. RESULTS: The optimal extraction technology was as follow as liquid-solid ratio of 18.5 ∶ 1, adding 75% ethanol, reflux extraction twice, 2.0 h each time. Average extraction yield of organic acids in verification test was 5.22% (RSD=2.70%, n=3), with 1.75% relative error of the predicted value (5.13%). CONCLUSIONS: Optimized extraction technology for organic acids in Crataegi fructus is simple, with good reproducibility and predictability.