OBJECTIVE： To establish a method for content determination of schizantherin E， gomisin J， angeloylgomisin H， schisantherin A， schisantherin B， schisanhenol， anwuligan， schizandrin A， schizandrin B and schizandrin C in Wuzhi tablets. METHODS： RP-HPLC method was adopted. The determination was performed on Symmetry C18 column with acetonitrile-0.1％ phosphoric acid solution （gradient elution） at the flow rate of 1.0 mL/min. The detection wavelength was set 225 nm， and the column temperature was 30 ℃. The sample size was 10 μL. RESULTS： The linear ranges of schizantherin E， gomisin J， angeloylgomisin H， schisantherin A， schisantherin B， schisanhenol， anwuligan， schizandrin A， schizandrin B and schizandrin C were 2.25-67.5 ng（r＝0.999 6）， 2.1-63 ng（r＝0.999 8）， 28-840 ng（r＝0.999 9）， 124.6-3 738 ng（r＝0.999 9）， 22.7-681 ng（r＝0.999 9）， 32.7-981 ng（r＝0.999 9），47-1 410 ng（r＝0.999 9）， 208-6 240 ng（r＝0.999 9）， 5.36-160.8 ng（r＝0.999 9）， 4.48-134.4 ng（r＝0.999 8）. The limits of quantitation were 14.17，13.32，9.33，11.37，14.62，19.88，14.66，12.50，16.40，13.55 ng. The limits of detection were 4.62，4.60，3.08，3.76，4.81，6.74，4.93，4.16，5.86，5.03 ng. RSDs of precision， stability and reproducibility tests were less than 3.0％； the recoveries were 96.36％-100.00％（RSD＝1.83％，n＝6）， 95.00％-100.00％（RSD＝2.07％，n＝6）， 95.00％-98.00％（RSD＝1.22％，n＝6）， 95.37％-98.91％（RSD＝1.29％，n＝6）， 95.62％-103.71％（RSD＝2.85％，n＝6）， 97.33％-102.67％（RSD＝2.00％，n＝6）， 95.00％-99.33％（RSD＝1.75％，n＝6）， 97.24％-104.93％（RSD＝2.63％，n＝6）， 95.00％-97.50％（RSD＝1.42％，n＝6）， 96.00％-102.00％（RSD＝2.45％，n＝6）， respectively. CONCLUSIONS： The developed method is accurate， sensitive and reproducible， and it can be used for content determination of 10 lignanoids in Wuzhi tablets.