OBJECTIVE： To observe clinical effect and safety of Shenfu injection combined with linezolid in the treatment of severe pneumonia caused by methicillin-resistant Staphylococcus aureus （MRSA）. METHODS： In retrospective study， 62 MRSA severe pneumonia patients selected from ICU of our hospital during Jun. 2012-Oct. 2015 were divided into observation group （25 cases） and control group （28 cases） according to medication plan. Based on routine treatment， control group was additionally given Linezolid injection 600 mg， ivgtt， bid. Observation group was additionally given Shenfu injection intravenously with initial dose of 60 mL， and then given continuous intravenous infusion of 60 mL at a rate of 20 mL/h， q12  h， on the basis of control group. Both groups were treated for consecutive 2 weeks. Clinical efficacy， bacteriological efficacy， cardiac function indexes and serum levels of inflammatory factors before and after treatment as well as the occurrence of ADR were compared between 2 groups. RESULTS： The clinical response rate of observation group was 88.00％， which was significantly higher than 60.71％ of control group， with statistical significance （P＜0.05）. Bacterial clearance rate of observation group was 72.00％， and that of control group was 64.28％， there was no statistical significance between 2 groups （P＞0.05）. Before treatment， there was no statistical significance in cardiac function indexes and serum inflammatory factor levels between 2 groups （P＞0.05）. After treatment， LVEF， SV， CO and CI of 2 groups were increased significantly compared to before treatment， while the levels of TNF-α， IL-6， CRP and PCT were decreased significantly； the indexes of observation group was significantly better than those of control group， with statistical significance （P＜0.05）. No severe ADR was found in 2 groups. CONCLUSIONS： Shenfu injection combined with linezolid effectively improves the cardiac function of patients with MRSA severe pneumonia， enhances the anti-inflammatory effect， and have a very significant clinic effect with good safety.