OBJECTIVE： To develop a method for simultaneous determination of chlorogenic acid， baicalin， aloe emodin， rhein， emodin， chrysophanol and physcione in Kangjun xiaoyan tablets. METHODS： RP-HPLC method was adopted. The determination was performed on Agilent Extend C18 with mobile phase consisted of acetonitrile-0.5％ phosohoric acid solution （gradient elution） at the flow rate of 1.0 mL/min. The detection wavelengths were set at 327 nm （chlorogenic acid）， 280 nm （baicalin） and 450 nm （aloe emodin， rhein， emodin， chrysophanol， physcione）. The column temperature was 30 ℃， and sample size was 10 μL. RESULTS： The linear ranges of chlorogenic acid， baicalin， aloe emodin， rhein， emodin， chrysophanol and physcione were 0.209 4-4.188 0 μg（r＝0.999 9），0.372 0-7.440 0 μg（r＝0.999 9），0.006 3-0.126 2 μg（r＝0.999 9），0.011 6-0.232 2 μg（r＝0.999 9），0.005 3- 0.106 0 μg（r＝0.999 8）， 0.012 8-0.256 4 μg（r＝0.999 9）， 0.016 5-0.330 3 μg（r＝0.999 8）， respectively. The limits of quantitation were 2.01， 1.93， 0.76， 1.25， 1.24， 0.53 and 1.53 ng； the limits of detection were 0.98， 0.65， 0.25， 0.42， 0.41， 0.18 and 0.52 ng， respectively. The recoveries were 98.41％-100.40％（RSD＝0.76％，n＝9），96.17％-100.10％（RSD＝1.58％，n＝9），96.11％-100.10％（RSD＝1.33％，n＝9）， 96.29％-100.80％（RSD＝1.85％，n＝9），96.88％-100.10％（RSD＝1.22％，n＝9），97.81％-101.90％（RSD＝1.64％，n＝9）， 96.46％-101.30％（RSD＝1.85％，n＝9）， respectively.  CONCLUSIONS： The method is accurate， reliable and reproducible. It can be used for simultaneous determination of 7 components in Kangjun xiaoyan tablets.