OBJECTIVE： To investigate clinical efficacy of intravenous drip of alprostadil combined with acupuncture in the treatment of diabetic foot ulcer and its effects on inflammatory factors levels and wound microvascular density. METHODS： A total of 72 patients with diabetic foot ulcer in our hospital during May 2014 to Sept. 2015 were divided into observation group and control group according to random number table， with 36 cases in each group. Control group was given Alprostadil injection 10 μg added into 250 mL 0.9％ Sodium chloride injection intravenously， qd， on the basis of routine treatment as insulin. Observation group was additionally given acupuncture therapy （Sanyinjiao， Zusanli， Fenglong， Yanglingquan， Yinlingquan and other acupuncture points）， qd， on the basis of control group.  Treatment courses of 2 groups lasted for 3 weeks. Clinical efficacy， wound healing time， fasting blood glucose， urine microalbumin， inflammatory factors， wound microvascular density as well as the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate of observation group （91.67％） was significantly higher than that of control group （72.22％）， and wound healing time was significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in fasting blood glucose， urine microalbumin and inflammatory factors between 2 groups （P＞0.05）. After treatment， above indexes of 2 groups were significantly lower than before， and urine microalbumin and inflammatory factors of the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. 14， 21 d after treatment， wound microvessel density of observation group was significantly higher those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Intravenous drip of Alprostadil combined with acupuncture can boost angiogenesis through mitigating inflammatory reactions， thus shorten the time of wound healing and enhance therapeutic efficacy.