OBJECTIVE： To optimize the water extraction technology of Punica granatum peel and flowers in Muzha suppository. METHODS： Using total tannin， ellagic acid contents as evaluation indexes， extration time， times， the amount of solvents as investigation factors， L9（34） orthogonal test was adopted to optimize the water extraction technology of P. granatum flowers and peel. And verification test was conducted. RESULTS： The optimal extraction technology of total tannin and ellagic acid in P. granatum peel and flowers was as follow as 10-fold water reflux extraction for 3 times with 2 herbs， 0.5 h every time. The average content of total tannin and ellagic acid extracted from 3 batches of herbs was 151.69 mg/g （RSD＝1.15％， n＝3）， 24.59 mg/g （RSD＝1.41％， n＝3） in the verification test， respectively. CONCLUSIONS： The optimized extraction technology is stable， feasible， and can be used for extracting the total tannin and ellagic acid in P. granatum peel and flowers.