OBJECTIVE： To evaluate the effects of clinical pharmacists participating in clinical pathway management for chronic heart failure （CHF）. METHODS： A total of 107 CHF adult inpatients in Linyi People’s Hospital during Jan. 2014-Oct. 2015 were divided into control group （56 cases， 3 withdrawal， 53 in total） and trial group （58 cases， 4 withdrawal， 54 in total） according to random number table. Control group received routine clinical pathway management method of CHF； trial group received clinical pathway management with the participation of clinical pharmacists. Clinical efficacy， the utilization of heart failure drugs， economic indexes， medication compliance after discharge， re-hospitalization rate due to heart failure were compared between 2 groups. RESULTS： Total response rate of trial group was significantly higher than control group， with statistical significance （P＜0.05）. The utilization rate of ACEI/ARB， β-receptor blocker， target dose rate of ACEI/ARB in trial group were significantly higher than control group， with statistical significance （P＜0.05）； target dose rate of β-receptor blocker was higher than control group， without statistical significance （P＞0.05）. Hospitalization time， drug cost， total hospitalization cost and drug ratio of trial group were shorter or lower than control group， without statistical significance （P＞0.05）. One month after discharge， the proportion of medication compliance in trial group was significantly higher than control group， with statistical significance （P＜0.05）； re-hospitalization rate was lower than control group， without statistical significance （P＞0.05）. Three months after discharge， the proportion of medication compliance in trial group was higher than control group， while re-hospitalization rate was lower than control group， with statistical significance （P＜0.05）. CONCIUSIONS： The participation of clinical pharmacists in clinical pathway management of CHF can significantly improve the utilization rate of recommended drugs by guideline， clinical efficacy and medication compliance， and reduce re-hospitalization rate.